Master level Internship project in assay development and HTS at COILED/PPSC
The Center of Open Innovation in Lead Discovery (COILED) is a unique drug discovery program that focuses on the delivery of next generation small-molecule immune-modulatory drugs. It is a close collaboration between Radboud University, Radboudumc, Inntrest Consultancy, Pivot Park Screening Centre, Pansynt and BioAxis Research.
COILED focuses on ‘trained immunity’, a phenomenon based on the ground-breaking research by Prof. Mihai Netea, at the Department of Experimental Internal Medicine at Radboudumc. Prof. Netea showed that, in contrast to more traditional views, the innate immune system has a memory. Mechanistic studies demonstrated that this trained immunity is based on reprogramming of the epigenetic code by specific histone-modifying enzymes. The result is that the DNA of the immune cells is left in a state of high alert for several months following an immunological insult or infection. Derailed innate immune memory plays a role in hypo- as well as hyper-inflammatory diseases furnishing new therapeutic avenues to treat unmet medical disease like cancer, rheumatoid arthritis and sepsis.
COILED consortium is looking for a master level student who will develop/optimize, miniaturize and implement biochemical assays for high-throughput screening. The successfully developed biochemical assay will be used by the student to screen drug-like compound libraries against two epigenetic targets within a state-of-the-art industrial screening facility. The daily work will be performed at the Pivot Park Screening Centre (Oss) in close collaboration with Radboud University.
Experience in assay development and theoretical background in biochemistry is a big plus. The student needs to be able to work independently in an output driven industrial setting, be proactive and eager to learn.
If you are interested or like to have more information, please contact Dr. Saman Honarnejad (firstname.lastname@example.org). Deadline: 30-April-2018
“I am studying Biology and Medical Laboratory research at the HAN, and I have fulfilled my first internship at the Assay Development group of the Pivot Park Screening Centre.
During these 20 weeks, I gained experience on new aspects of biomedical laboratory research, such as antibiotic-free cell culturing and mycoplasma tests, the optimization of luminescence assays and manual/automated dispensing on 348-well and 1536-well format. I have been supervised very well, and felt welcome at the Screening Centre team. This internship was a good experience for both my personal and professional development.”
“For my education, biotechnology analyst, I had to do an internship, which I did at Pivot Park Screening Centre (PPSC). There I joined the operators team, for a period of 20 weeks.
I had a lot of fun and I learned quite a few new things. The employees were always willing to help me whenever I had a question. They also appreciated it when you introduced new ideas or solutions. In the end, I experienced an amazing first internship experience thanks to the PPSC and its employees.”
I was in my 3rd year of my bachelor life science when I did my internship at Pivot Park. I worked on the department assay development, where I developed cell based GPCR/RTK assays for high throughput screening. The internship lasted about 5 months and in that time I’ve learned a lot.
It was my first internship and I got a supervisor who gave me explanations, time and space to work with him but eventually on my own. He helped me in the lab but also with my report.
The group assay development works together with the robot operators in a fine co-operation, where questions can be asked all the time. The departments are always prepared to help you and make you look back on a fun and educational time.