A career with a sense of purpose

Together we can improve global health

Do you want to contribute to drug discovery?

Our colleagues, together with other business partners and knowledge institutes, work towards discovering new medicines in order to achieve a healthier society.

 

Do you want to progress in the field of drug discovery?

We are specialised in scientific research and provide highly regarded screening assignments and research programmes. Our long-standing experience in early drug discovery and our state-of-the-art Ultra-High-Throughput Screening infrastructure provides us and our partners with the best confirmed leads.

 

Do you want to expand your knowledge and experience?

WWe are always keen to meet potential new scientist colleagues, and if you’re interested we will show you around our campus with great pride and enthusiasm. You’re welcome to visit and enjoy a cup of coffee with us. Or just share your CV and a letter which tells us what you are looking for. Please, send us an e-mail.

Vacancies

 

Pivot Park Screening Centre (PPSC) is a quickly growing company in drug discovery research with a main focus on ultra-high throughput screening. Using our state-of-the-art robotic systems we work together with customers ranging from big pharma companies to small & medium biotech companies and universities. We offer services in early drug discovery in the field of assay development, compound screening and biological profiling during hit to lead phase. PPSC is also actively involved in the European Lead Factory (ELF; IMI initiative) as the beating heart of the European Screening Centre. Besides strengthening the PPSC core business we are also expanding in areas like Hit-to-Lead profiling and precision medicine. To support this growth we are looking for PhD level scientists.

 

Job Description

Pivot Park Screening Centre is looking for a PhD level Chemical Biologist with medicinal chemistry knowledge to expand our capacity to support all the early drug discovery programmes. We are looking for a proactive, experienced, enthusiastic and motivated social colleague to join the assay development department (currently 10 people). In close collaboration with assay development and screening team leaders, you will lead international HTS and assay development project teams with possibilities to carry out assay development work at the bench in the laboratory, supervise technicians and contribute to writing and reviewing reports, (inter-) national proposals and scientific journals.

 

An important development at PPSC is the introduction of MALDI-TOF screening in ultra-high throughput format. Therefore, we look for candidates with at least 2-3 years of experience in the field of Mass Spectrometry. This position aims to strengthen our chemical expertise in projects. Therefore, we are specifically looking for a scientist who understands molecular interactions at the intersection of biology and chemistry, so that liabilities in assay development can be identified and resolved. Furthermore, your medicinal chemistry knowledge is applied to evaluate HTS active/hit lists in order to decide which compounds are best to follow up.

 

The position we offer is initially for 1 year with possibility for extension or even a permanent position.

 

Our job requirements:

  • PhD degree in chemical biology, (bio)chemistry, or molecular life sciences
  • Experience in biochemical and cell-based assay development
  • Experience in medicinal chemistry
  • Thorough understanding of molecular interactions
  • Experience in Mass Spectrometry
  • Affinity for lab automation and knowledge of general IT
  • Experience in Project management, reporting and writing;
  • Good communication skills, in Dutch and English
  • Good collaboration skills

 

Application:

Are you enthusiastic about what Pivot Park Screening Centre has to offer you and you are interested to apply? Please do send your CV and motivation via email to:

 

Hanny Faro, HR Business Partner

hanny.faro@pivotpark.com

Pivot Park Screening Centre (PPSC) is a quickly growing company in drug discovery research located on the Pivot Park in Oss, a successful campus with more than 55 company specializing in drug discovery and development.  PPSC is a spin-out company from MSD and we use state-of-the-art robotic systems to test 100.000-1.000.000 compounds to find new starting points for medicines in a wide range of therapeutic areas. We work together with big pharma companies across Europe. In addition, we are the main participant in the European Lead Factory (ELF). This EU funded initiative is the largest public private partnership in the field of drug discovery and brings together pharma companies, universities and SME to boost drug discovery in Europe. Being the beating heart of ELF, PPSC is at the forefront of drug discovery research in Europe. We deliver starting points for future medicines.

 

We are looking for motivated students that wish to help in the field of assay development and optimize an assay for automated screening.

 

Examples of topics in this project:

  • Assay development of a biochemical or cellular assay, using a protein, enzyme or receptor of interest.
  • Optimize this assay to 384-well and 1536-well format for automated screening.
  • After this optimization process perform a screen using a subset of our compound collection.
  • Analyze the data using dedicated software.

 

Examples of techniques used in this project:

  • Perform 384-well assays on the bench using automated pipettes.
  • Perform 1536-well assays using state of the art lab automation equipment.
  • General cell culture techniques and cell culture techniques focused on screening such as the use of “frozen cells” and culturing in roller bottles.
  • The use of different read-out techniques such as luciferase, FRET, Fluorescence intensity, HTRF, Alphascreen, Membrane potential Calcium fluxes.

 

We are looking for a late-stage student that can work with us on one or more of these topics. The ideal candidate:

  • Has a basic understanding of biochemistry.
  • Is interested in life sciences applications.

 

Send us your CV and motivation letter in case you would like to apply for this internship.

Pivot Park Screening Centre (PPSC) is a quickly growing company in drug discovery research located  on the Pivot Park in Oss, a successful  campus with more than 55 company specializing in drug discovery and development.  PPSC is  a spin-out company from MSD and we use state-of-the-art robotic systems to test 100.000-1.000.000 compounds to find new starting points for medicines in a wide range of therapeutic areas. We work together with big pharma companies across Europe. In addition, we are the main participant in the European Lead Factory (ELF). This EU funded initiative is the largest public private partnership in the field of drug discovery and brings together pharma companies, universities and SME to boost drug discovery in Europe. Being the beating heart of ELF, PPSC is at the forefront of drug discovery research in Europe. We deliver starting points for future medicines.

 

As large volumes of data are produced in High-Throughput Screening (HTS), PPSC needs sophisticated software tools to handle this efficiently. Recently new software has been implemented that supports our basic workflows. With these workflows in place, and data stored in databases, PPSC has started a project to increase quality of workflows and learn from the data by mining the results databases. We are looking for motivated students that wish to help answering our questions in the field of data sciences.

 

Examples of topics in this project:

  • Determine the occurrence of duplicate structures in compound libraries and analyse corresponding biological results to establish reproducibility of biological results in the database.
  • A special set of compounds is used to test the robustness of assays during assay development. A cross program analysis is needed to evaluate the usefulness of this approach and make recommendations for future application.
  • Some compounds in our library show up as active in many different assays. These are called “frequent hitters” and are not of interest for further investigation in a project because they are the result of artefacts in the assays. An analysis of frequent hitters is needed to investigate whether they have properties in common and how we can label them to enable more efficient handling in future.
  • Evaluate compound logistics software and implement templates & workflows
  • Investigate and apply workflow software (KNIME) to streamline data analysis

 

We are looking for a late-stage student that can work with us on one or more of these topics. The ideal candidate:

  • Is experienced with data sciences in general. Ideally you have some experience in programming and/or data processing.
  • Has a basic understanding of chemistry.
  • Is interested in life sciences applications.

 

Send us your CV and motivation letter in case you would like to apply for this internship.