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Category: Publications

Label-free Mass Spectrometry ultra-HighThroughput Screening

A game-changer in small molecule lead discovery. Pivot Park Screening Centre (PPSC) is the first contract research organization (CRO) that

INFOGRAPHIC: Label free mass spec uHTS

Our automated ultra-High-Throughput Screening (uHTS) platform is expanded with the rapifleX® MALDI PharmaPulse® (Bruker AG) along with CyBio Well Vario system (Analytik Jena AG).

Is you assay amendable to uHTS? Seven aspects to assess

Is your assay amendable to ultra-High-Throughput Screening? Seven aspects to consider…

Beyond doubt, major improvements in robotics and flexible automation over the last decades have made uHTS a mainstay in hit

Five reasons to outsource a screen at Pivot Park Screening Centre

Five reasons for a startup to outsource a screen to PPSC

Even though the success rates in discovery and development of new medicines remain extremely low, many innovative biotech companies are

Hit Discovery for Public Target Programs in the European Lead Factory: Experiences and Output from Assay Development and Ultra-High-Throughput Screening

Honarnejad, S., van Boeckel, S., van den Hurk, H., & van Helden, S. (2020). Hit Discovery for Public Target Programs

High-Throughput Fluorescence-Based Activity Assay for Arginase-1

Grobben, Y., Willemsen-Seegers, N., Uitdehaag, J. C. M., de Man, J., van Groningen, J., Friesen, J., … Zaman, G. J.

Discovery of a NAPE-PLD inhibitor that modulates emotional behavior in mice

Mock, E.D., Mustafa, M., Gunduz-Cinar, O. et al. Discovery of a NAPE-PLD inhibitor that modulates emotional behavior in mice. Nat

Synthesis and Structure‐Activity Relationships of N‐(4‐Benzamidino)‐Oxazolidinones: Potent and Selective Inhibitors of Kallikrein‐Related Peptidase 6

De Vita, E., Smits, N., van den Hurk, H.; et al. Synthesis and Structure-Activity Relationships of N-(4-Benzamidino)-Oxazolidinones: Potent and Selective

High throughput screening in calcium transient assay to assess cardiotoxicity of compounds using hiPSC-derived cardiomyocytes

Farbod Famili, Tsang Wai Lam, Pieter van Loenen, Peter Nacken, Maaike Bras, Saman Honarnejad, Yang Jiang, Viola Borgdroff, Heribert Bohlen, Arie Reijerkerk, Helma Rutjes, Stefan Braam, Greg Luermanc. (2019). Journal of Pharmacological and Toxicological Methods.

Identification of a Novel Class of Benzofuran Oxoacetic Acid-Derived Ligands that Selectively Activate Cellular EPAC1

Beck, E.M.; Parnell, E.; Cowley, A.; Porter, A.; Gillespie, J.; Robinson, J.; Robinson, L.; Pannifer, A.D.; Hamon, V.; Jones, P.;