At Pivot Park Screening Centre, we have longstanding and proven experience in ultra-High Throughput Screening (uHTS), enabling us to support and accelerate your lead discovery project.
From assay development and miniaturization, to uHTS campaigns, hit triaging, cheminformatics and even further into hit-to-lead profiling. Our experience enables us to execute unparalleled uHTS campaigns, and to develop the most suitable hit-identification strategy, ensuring the identification of tractable chemical starting points that can be developed further to lead candidates.
At Pivot Park Screening Centre, we offer state-of-the-art and flexible automation for ultra-High Throughput Screening using a variety of assay formats (biochemical, cellular, biophysical) in 96-, 384- or 1536-well format to find and optimise novel chemical starting points for drug development. By outsourcing your ultra-high throughput screening campaigns to our passionate team, you can benefit from our longstanding experience with the most challenging targets and assays, pharma-standard infrastructure and operations and most importantly accelerate your lead discovery program.
Our industrial uHTS platform allows us to generate 100,000-300,000 high-quality data points per day. Besides our in-house diversity-based 300,000 IP-free compound library, we can screen your own propriatory library, or third librararies irrespective of size. We can also store a copy of your library for multiple screening campaigns.
Start your uHTS campaign now using large compound libraries to rapidly explore large and biologically relevant chemical space affordably to give a head start and de-risk your drug discovery program. We can help you to scale up and miniaturise your assays to 96-, 384- or 1536-well formats for Medium, High or ultra-High Throughput Screening. We have a phenominal track record in scaling up assays to 1536-well plate format, enabling large-scale screening campaigns at low cost and in short timelines.
Our uHTS lab hosts a fully automated, robotic system in an industrial set-up, to assist your drug discovery process. This is a system which runs efficient biochemical and cellular HTS assay technologies (absorbance, luminescence, fluorescence or Mass-spec based) in 384- or 1536-well formats and can produce over 300,000 data points per day.
Our advanced ultra-High Throughput Screening (uHTS) system consists of 3 robot pods connected by a conveyer belt system. It features an on-line compound store with capacity for 2.5 million samples, ECHO acoustic dispensers for contact free dispensing and a wide range of instruments to perform biochemical and cellular assays in 1536- or 384-well format in a fully automated manner. Over 200,000 data samples are routinely measured per day.
Acoustic dispensing technology allows for contact-free, low-volume handling of compound solutions and facilitates online cherry-picking of active compounds. Our complete infrastructure, including fully automated data analysis software and transparent pipeline, guarantees full exploitation of high quality results.
We have many different readout technologies in-house including most conventional label-based biochemical and cellular readouts such as Flourescence, FRET/HTRF/TR-FRET, FP, Luminescence, absorption, high-content, phenotypic, as well as label-free MALDI-TOF mass spectrometry biochemical, affinity-based and cellular assays.
✔ Integrated approach for early drug discovery
✔ Handling of large customer compound libraries
✔ Big pharma-like uHTS set-up and top-notch read-out technologies
✔ Very experienced screening site for ELF & pharma-accounts
✔ Broad knowledge in different assay development-solutions
✔ From disease targets to high-quality starting points for drug development
Interested? Get in touch and we’ll help you accelerate your drug discovery.
Ultra-High-Throughput Screening infrastructure in a nutshell. Watch our video
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Most instruments are placed on carts so that the system configuration can be adapted to the needs of specific projects. This flexible docking system designed by HighRes Biosolutions® also allows for easy integration of new technologies/instruments. A custom designed safety system ensures that individual instruments can be accessed during a run.
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