We offer state-of-the-art automation for low to ultra-High-Throughput Screening to find and optimise novel leads for drug development. We can help you miniaturise your assays to 96-, 384- or 1536-well formats for Low, Medium or High-Throughput Screening including hit validation, hit-to-lead and lead optimisation.
Our uHTS lab hosts a fully automated, state-of-the-art, robotic system in an industrial set-up, to assist your drug discovery process. This is a system which runs efficient biochemical and cellular HTS assay technologies (absorbance, luminescence, fluorescence based) in 384- or 1536-well formats and can produce over 300,000 data points per day.
Acoustic dispensing technology allows for contact-free, low-volume handling of compound solutions and facilitates online cherry-picking of active compounds. Our complete infrastructure, including fully automated data analysis software and transparent pipeline, guarantees full exploitation of high quality results.
Our advanced ultra-High-Throughput Screening (uHTS) system consists of 3 robot pods connected by a conveyer belt system. It features an on-line compound store with capacity for 2.5 million samples, ECHO acoustic dispensers for contact free dispensing and a wide range of instruments to perform biochemical and cellular assays in 1536- or 384-well format in a fully automated manner. Over 200,000 data samples are routinely measured per day.
✔ Integrated approach for early drug discovery
✔ Handling of large customer compound libraries
✔ Big pharma-like uHTS set-up and top-notch read-out technologies
✔ Very experienced screening site for ELF & pharma-accounts
✔ Broad knowledge in different assay development-solutions
✔ From disease targets to high-quality starting points for drug development
Interested? Get in touch and we’ll help you accelerate your drug discovery.
Ultra-High-Throughput Screening infrastructure in a nutshell. Watch our video
Read all about the 5 reasons to outsource a screen at PPSC
Webinar-on-demand: Hit discovery using the rapifleX Maldi PharmaPulse® in uHTS
In this webinar we will focus on label-free mass spectromety technology. Pivot Park Screening Centre (PPSC) will present the integration and the first succesful campaign of over 0.5 million compounds using label-free mass spectrometry technology.
Webinar-on-demand: Hit discovery for trained immunity and tolerance
Watch this webinar to learn about trained immunity, the role of epigenetic targets in trained immunity, hit discovery through ultra-High throughput screening of large libraries & industry standard H2L biological profiling frameworks.
Webinar on-demand: Hit finding for crowd-sourced disease targets
Watch this webinar to learn about Pivot Park Screening Centre (PPSC) contributions to the European Lead Factory (ELF), hit finding efforts for > 70 crowd-sourced drug targets & lessons learnt from assay development and uHTS output within ELF.
Most instruments are placed on carts so that the system configuration can be adapted to the needs of specific projects. This flexible docking system designed by HighRes Biosolutions® also allows for easy integration of new technologies/instruments. A custom designed safety system ensures that individual instruments can be accessed during a run.
Pivot Park – Banting Building (RE2423)
Kloosterstraat 9
5349 AB Oss
The Netherlands
Pivot Park – RE2423
Industrielaan 63
5349 AE Oss
The Netherlands
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