State-of-the-art automation for low to

ultra-High-Throughput Screening

Infrastructure

We offer state-of-the-art automation for low to ultra-High-Throughput Screening to find and optimise novel leads for drug development. We can help you miniaturise your assays to 96-, 384- or 1536-well formats for Low, Medium or High-Throughput Screening including hit validation, hit-to-lead and lead optimisation.

How we help you to accelerate
your drug discovery programme

Ultra-High-Throughput Screening infrastructure in a nutshell. Watch our video

Our uHTS lab hosts a fully automated, state-of-the-art, robotic system in an industrial set-up, to assist your drug discovery process. This is a system which runs efficient biochemical and cellular HTS assay technologies (absorbance, luminescence, fluorescence based) in 384- or 1536-well formats and can produce over 300,000 data points per day.

Acoustic dispensing technology allows for contact-free, low-volume handling of compound solutions and facilitates online cherry-picking of active compounds. Our complete infrastructure, including fully automated data analysis software and transparent pipeline, guarantees full exploitation of high quality results.

Our advanced ultra-High-Throughput Screening (uHTS) system consists of 3 robot pods connected by a conveyer belt system. It features an on-line compound store with capacity for 2.5 million samples, ECHO acoustic dispensers for contact free dispensing and a wide range of instruments to perform biochemical and cellular assays in 1536- or 384-well format in a fully automated manner. Over 200,000 data samples are routinely measured per day.

Take a closer look

uHTS Equipment

Most instruments are placed on carts so that the system configuration can be adapted to the needs of specific projects. This flexible docking system designed by HighRes Biosolutions® also allows for easy integration of new technologies/instruments. A custom designed safety system ensures that individual instruments can be accessed during a run.

Benefits of automation

Our automated workflows produce high-quality data in a consistent manner. Assays can be run outside business hours enabling fast turn-around times. Combined with miniaturisation to 1536-well format, a high-quality, efficient and cost saving setup is offered to our clients.