At Pivot Park Screening Centre, we have longstanding and proven experience in ultra High Throughput Screening (uHTS), enabling us to support and accelerate your lead discovery project.
From assay development and miniaturization, to uHTS campaigns, hit triaging, cheminformatics and even further into hit-to-lead profiling. Our experience enables us to execute unparalleled uHTS campaigns, and to develop the most suitable hit-identification strategy, ensuring the identification of tractable chemical starting points that can be developed further to lead candidates.
At Pivot Park Screening Centre, we offer state-of-the-art and flexible automation for ultra High Throughput Screening using a variety of assay formats (biochemical, cellular, biophysical) in 96-, 384- or 1536-well format to find and optimize novel chemical starting points for drug development. By outsourcing your ultra-high throughput screening campaigns to our passionate team, you can benefit from our longstanding experience with the most challenging targets and assays, pharma-standard infrastructure and operations and most importantly accelerate your lead discovery program.
Our industrial uHTS platform allows us to generate 100,000-300,000 high-quality data points per day. Besides our in-house diversity-based 300,000 IP-free compound library, we can screen your own proprietary library, or third libraries irrespective of size. We can also store a copy of your library for multiple screening campaigns.
Start your uHTS campaign now using large compound libraries to rapidly explore large and biologically relevant chemical space affordably to give a head start and de-risk your drug discovery program. We can help you to scale up and miniaturize your assays to 96-, 384- or 1536-well formats for Medium, High or ultra High Throughput Screening. We have a phenominal track record in scaling up assays to 1536-well plate format, enabling large-scale screening campaigns at low cost and in short timelines.
Our uHTS lab hosts a fully automated, robotic system in an industrial set-up, to assist your drug discovery process. This is a system which runs efficient biochemical and cellular HTS assay technologies (absorbance, luminescence, fluorescence or Mass-spec based) in 384- or 1536-well formats and can produce over 300,000 data points per day.
Our advanced ultra High Throughput Screening (uHTS) system consists of 3 robot pods connected by a conveyer belt system. It features an on-line compound store with capacity for 2.5 million samples, ECHO acoustic dispensers for contact free dispensing and a wide range of instruments to perform biochemical and cellular assays in 1536- or 384-well format in a fully automated manner. Over 200,000 data samples are routinely measured per day.
Acoustic dispensing technology allows for contact-free, low-volume handling of compound solutions and facilitates online cherry-picking of active compounds. Our complete infrastructure, including fully automated data analysis software and transparent pipeline, guarantees full exploitation of high quality results.
We have many different readout technologies in-house including most conventional label-based biochemical and cellular readouts such as Flourescence, FRET/HTRF/TR-FRET, FP, Luminescence, absorption, high-content, phenotypic, as well as label-free MALDI-TOF mass spectrometry biochemical, affinity-based and cellular assays.
Interested? Get in touch and we’ll help you accelerate your drug discovery.
Ultra High Throughput Screening infrastructure in a nutshell. Watch our video
Read all about the 5 reasons to outsource a screen at PPSC
We started a program to identify novel hits that inhibit the interaction between the viral spike protein subunit S1 and human angiotensin-converting enzyme 2 (hACE2).
Can uHTS be exploited to identify novel compounds against protein multimerization?
In this webinar we provide an overwiew of application demands for a reliable sample preparation automation and highlight the challenges that need to be overcome to improve lab processes
Webinar-on-demand: Could Mass Spec be the next break-through in High-Throughput Screening?
In this webinar we will present the implementation and capabilities of Mass Spec-uHTS as a fully automated screening platform and future applications of MS-uHTS.
Most instruments are placed on carts so that the system configuration can be adapted to the needs of specific projects. This flexible docking system designed by HighRes Biosolutions® also allows for easy integration of new technologies/instruments. A custom designed safety system ensures that individual instruments can be accessed during a run.
Pivot Park – Banting Building (RE600)
Kloosterstraat 9
5349 AB Oss
The Netherlands
Pivot Park Screening Centre
Building OP
Kloosterstraat 9
5349 AB Oss
The Netherlands
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