State-of-the-art automation for low to
ultra-High-Throughput Screening

Ultra-High Throughput Screening (uHTS) lab

Our uHTS lab hosts a fully automated, robotic system in an industrial set-up, to assist your drug discovery process. This is a system which runs efficient biochemical and cellular HTS assay technologies (absorbance, luminescence, fluorescence or Mass-spec based) in 384- or 1536-well formats and can produce over 300,000 data points per day.

uHTS features

Our advanced ultra-High-Throughput Screening (uHTS) system consists of 3 robot pods connected by a conveyer belt system. It features an on-line compound store with capacity for 2.5 million samples, ECHO acoustic dispensers for contact free dispensing and a wide range of instruments to perform biochemical and cellular assays in 1536- or 384-well format in a fully automated manner. Over 200,000 data samples are routinely measured per day.

Acoustic dispensing technology

Acoustic dispensing technology allows for contact-free, low-volume handling of compound solutions and facilitates online cherry-picking of active compounds. Our complete infrastructure, including fully automated data analysis software and transparent pipeline, guarantees full exploitation of high quality results.

Readout technologies

We have many different readout technologies in-house including most conventional label-based biochemical and cellular readouts such as Flourescence, FRET/HTRF/TR-FRET, FP, Luminescence, absorption, high-content, phenotypic, as well as label-free MALDI-TOF mass spectrometry biochemical, affinity-based and cellular assays.

What makes us unique?

  Integrated approach for early drug discovery 

  Handling of large customer compound libraries

  Big pharma-like uHTS set-up and top-notch read-out technologies

  Very experienced screening site for ELF & pharma-accounts

  Broad knowledge in different assay development-solutions

  From disease targets to high-quality starting points for drug development

Interested? Get in touch and we’ll help you accelerate your drug discovery.

How we help you to accelerate
your drug discovery programme

Ultra-High-Throughput Screening infrastructure in a nutshell. Watch our video

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Take a closer look

uHTS Equipment

Most instruments are placed on carts so that the system configuration can be adapted to the needs of specific projects. This flexible docking system designed by HighRes Biosolutions® also allows for easy integration of new technologies/instruments. A custom designed safety system ensures that individual instruments can be accessed during a run.

Benefits of automation
Our automated workflows produce high-quality data in a consistent manner. Assays can be run outside business hours enabling fast turn-around times. Combined with miniaturisation to 1536-well format, a high-quality, efficient and cost saving setup is offered to our clients.

Thank you for you interest!

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