Validate target engagement early

in drug discovery

Target engagement is the cornerstone for validating hit matters identified in HTS campaigns. ​PPSC can rapidly profile target engagement and residence time through kinetic cellular read-outs as well as biophysical assays such as Thermal Shift Assay (TSA) and Surface Plasmon Resonance (SPR), providing a more refined hit validation.

 

Our experience in biophysical assay development and expertise in interpreting the data from hit biophysical characterisation ensures direct interaction of hits with target proteins and assists with chemotype prioritisation.

Biophysical Characterisation