New approaches for hit discovery against Ion Channels and GPCRs using the Fluorescent Imaging Plate Reader (FLIPR) technology.
Ion channels and G protein-coupled receptors (GPCRs) are major drivers of human physiology, orchestrating a myriad of physiological processes. Ion channels govern the flux of ions across cell membranes, regulating electrical excitability in cells such as neurons and muscle cells. Concurrently, GPCRs, the largest family of membrane-bound receptors, transduce extracellular signals to intracellular responses, playing a crucial role in mediating responses to neurotransmitters, hormones, and other signaling molecules. Both ion channels and GPCRs are integral to processes like synaptic transmission, muscle contraction, and hormone secretion. Dysregulation of these signaling pathways can lead to a spectrum of diseases, including neurological disorders, cardiovascular diseases, and endocrine abnormalities. Investigating the intricate interplay between ion channels and GPCRs has not only deepened our understanding of basic physiological processes, but has also provided crucial insights into the development of targeted therapies for a range of diseases, underscoring their importance in maintaining human health.
Pivot Park Screening Centre has ample experience in running FLIPR-based assays in 1536-well plate format for both GPCR and ion channel target classes. Read about the showcase in the whitepaper below.
